If you Exit / Quit everything and Restart your computer - 2 times - and you still get a good response re Profiles, then you are probably OK.
Remember the access to the Profile Picker: brave://profile-picker/
Another Windows OS update, or Brave Browser update, or extension update, might cause the issue again; but now you will be better prepared.
My consolidated notes re data backup:
‘Brave deleted all my active tabs and favorites - #2 by 289wk’